Genetic factors influencing risk to orofacial clefts: today’s challenges and tomorrow’s opportunities
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چکیده
منابع مشابه
Genetic factors influencing risk to orofacial clefts: today’s challenges and tomorrow’s opportunities
Orofacial clefts include cleft lip (CL), cleft palate (CP), and cleft lip and palate (CLP), which combined represent the largest group of craniofacial malformations in humans with an overall prevalence of one per 1,000 live births. Each of these birth defects shows strong familial aggregation, suggesting a major genetic component to their etiology. Genetic studies of orofacial clefts extend bac...
متن کاملGenetic factors influencing risk to orofacial clefts: today’s challenges and tomorrow’s opportunities [version 1; referees: 2 approved]
Orofacial clefts include cleft lip (CL), cleft palate (CP), and cleft lip and palate (CLP), which combined represent the largest group of craniofacial malformations in humans with an overall prevalence of one per 1,000 live births. Each of these birth defects shows strong familial aggregation, suggesting a major genetic component to their etiology. Genetic studies of orofacial clefts extend bac...
متن کاملCorticosteroid use and risk of orofacial clefts
BACKGROUND Maternal use of corticosteroids during early pregnancy has been inconsistently associated with orofacial clefts in the offspring. A previous report from the National Birth Defect Prevention Study (NBDPS), using data from 1997 to 2002, found an association with cleft lip and palate (odds ratio, 1.7; 95% confidence interval [CI], 1.1-2.6), but not cleft palate only (odds ratio, 0.5, 95...
متن کاملStudy of risk factors related to the orofacial clefts in Eastern Azerbaijan, Iran: Population-based from 2000 to 2015
Background and aims: Nowadays, Orofacial clefts are known as the most common orofacial birth defects. Several factors are responsible for problem, such as environmental factors, genetic background, nutritional deficiencies such as Vitamins, zinc, iron, maternal diseases, exposure to teratogenicagents, smoking, drugs, organic solvents. The aim of this study was to evaluate the o...
متن کاملEpidemiology of Orofacial clefts in Africa: Methodological challenges in ascertainment
BACKGROUND To carry out a systematic review of the birth prevalence of cleft lip with or without cleft palate (CLP) and cleft palate (CP) in Africa based on available published data. METHOD Using the Cochrane search strategy and the following keywords words "cleft palate", "prevalence", "incidence", "cleft lip" and "Africa" to screen Ovid Medline {1966 to March 2007), Cinahl {1982-March 2007}...
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ژورنال
عنوان ژورنال: F1000Research
سال: 2016
ISSN: 2046-1402
DOI: 10.12688/f1000research.9503.1